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In some cases, when taken long term or in high doses, oxycodone can cause constipation, itching or hives; slowed breathing; confusion; impaired thinking and judgement; weak pulse; extreme drowsiness; low blood pressure; vomiting (sometimes leading to dangerous breathing problems); addiction/dependence/tolerance issues in some people, who start to need higher doses to get similar effects (though tolerance will build more slowly in older adults than in younger adults); mood changes including depression or suicidal thoughts (especially when used for a long time or at high doses), anxiety (especially when used at high doses), irritability and insomnia.

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